Juvederm is an injectable dermal filler made from cross-linked hyaluronic acid. Hyaluronic acid diminishes with age, contributing to the formation of fine lines, wrinkles and folds. Hyaluronic acid is a natural substance that already exists in the human body and it gives the skin fullness. Juvederm restores natural volume, which tends to decrease with age and sun damage. Juvederm is a dermal filler which is injected into the skin to plump up the skin, make it firmer and smooth out lines and wrinkles.
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Juvederm is used in the upper and lower lips, in what is called the nasal labial folds. Juvederm is also used in the marionette or puppet lines. Some people also have Juvederm injected in the eyelid area, specifically in the glabella area. Sometimes, Juvederm is injected around the crow's feet, and also in an area called the malar bags, or the area below the eyes.
Juvederm is used for the treatment of the following situations:
- Facial lines
- Wrinkle correction
- Shaping facial contours (such as cheeks and chin correcting)
- Smile lines (correcting thin, superficial lines around the eyes, mouth and forehead)
- Most types of scars
- Lip enhancement
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The active ingredient of Juvederm is non-animal highly cross-linked hyaluronic acid. Hyaluronic acid, in it’s natural form, is a liquid which the body metabolizes very quickly. Cross-linking is a process that chemically binds the individual chains of hyaluronic acid together so that it is changed into a gel which lasts much longer once injected under the skin of the face.
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Juvederm improves your appearance by lifting and adding volume to the wrinkles and folds in the treatment area. After six to nine months, the biocompatible compound is naturally absorbed into the body.
Hyaluronic acid can absorb up to 1000 times its own weight in water, thereby adding new volume under the surface of sagging skin.
According to the manufacturer, Juvederm also continues working as time goes on by adding even more collagen to the face. Hyaluronic acid stretches cells in skin, known as fibroblasts, in a way that causes the skin to create new collagen. Hyaluronic acid also seems to stop the breakdown of existing collagen.
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Juvederm has been available in Europe since 2000. Juvederm became available in Canada in 2002. In the U.S., Juvederm became FDA-approved in 2006. Product became available in the U.S. in early 2007.
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Juvederm Ultra and Juvederm Ultra Plus are indicated for injection into the mid to deep dermis for correction of moderate to severe facial wrinkles and folds (such as nasolabial folds).
Typical Juvederm treatments include smoothing and contouring smile lines or nasolabial folds, wrinkles at the corner of the mouth, lip enhancement and augmentation, acne scars, facial defects or recessions, frown lines, modest enhancement or correcting asymmetrical features.
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The benefits of Juvederm include:
- Safe and effective nonsurgical option for softening fine lines and wrinkles and restoring lost volume.
- No allergy skin tests are needed prior to receiving treatment.
- obtained by biosynthesis and is of non-animal origin.
- results last up to 1 year, longer than other hyaluronic acid dermal fillers.
- Immediate results
- hyaluronic acid content is currently one of the most concentrated on the market.
- patented HYLACROSS™ technology to provide one of the highest concentrations of cross-linked hyaluronic acid of any currently available HA dermal filler for long-lasting results.
- smooth consistency gel that provides you with a smooth, natural look and feel.
- the only filler available with this smooth consistency gel–other existing hyaluronic acid dermal fillers are made of granular gels.
- first hyaluronic acid dermal filler that has demonstrated its safety and effectiveness in persons of colour.
- minimal recovery or downtime.
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Juvederm is injected directly into the skin in tiny amounts by an ultra fine needle, resulting in minimal discomfort. The smooth consistency of JUVEDERM dermal filler also may help to minimize the discomfort that can sometimes occur during the injection procedure. To make the procedure more comfortable local anesthetic or a topical numbing cream can be used to numb the treatment area.
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Before the Juvederm treatment, your doctor will determine the best injection sites for you. Usually, the area will then be numbed with a topical anesthetic before the Juvederm injections are done. The Juvederm gel is then injected just beneath the skin surface with a very fine needle to smooth away lines, restore natural contours and enhance lips for a smooth, natural and refreshed appearance. The filler remains in the skin where it binds water to produce a lift and firmness to the treated areas.
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A Juvederm treatment typically takes 15-30 minutes.
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How soon will I see results from my Juvederm injections?
You will see almost instantaneous results. By the time you leave the doctor's office, you'll see most of the lines/wrinkles of the treated area have either disappeared or shrunk substantially.
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Immediately after the Juvederm treatment, you can expect to see slight redness and swelling and to feel tenderness or an itching sensation in the treated area. This is a normal result of the injection. The discomfort is temporary and generally goes away within a day or two. After a Juvederm lip treatment, the lips may become swollen and look somewhat uneven. This can persist for a few days (up to a week). If the discomfort continues you should contact your physician.
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With Juvederm you can expect to see almost instantaneous improvement in treatment areas. Lines and wrinkles fill up very quickly. By the time you leave the doctor's office, you will see that most of your lines and wrinkles have either disappeared or shrunk substantially. Most patients should return two weeks after the initial Juvederm treatment so that they can have re-injections of Juvederm to fix any lines or wrinkles that may still be around. Most patients need one treatment to achieve optimal wrinkle smoothing, and the results last up to 6 months or more. However, results may vary and correction is temporary. Supplemental "touch up" treatments may be required to achieve and maintain optimal results.
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Juvederm has been used successfully and safely in Europe since 2000. Juvederm has been used in Canada since 2002 and received FDA approval in 2006. Juvederm has proven itself as a safe and effective injectable dermal filler.
Juvederm is newer cosmetic dermal filler but has a good safety record.
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No head-to-head clinical trials have been performed to compare Juvederm vs. Restylane. However, some doctors already report more favorable results with Juvederm. According to Dr. Gregory Buford, "Juvederm also gives the patients less lumpiness . . . which was a common problem with the previous filler, Restylane."
Medicis, the U.S. distributor of Restylane, has sent letters to dermatologists, plastic surgeons, and other physicians claiming that Juvederm safety is not assured.
Specifically, Medicis calls into question the safety of using Juvederm on anyone who's had Restylane in the past. The interaction of these drugs has not been tested. Allergan, the maker of Juvederm, argues that the products contain nearly identical active ingredients so worries about interactions are unfounded.
The main difference between the two dermal fillers is in the level of smoothness with Juvederm being twice as smooth as Restylane, according to one Seattle-based Facial Plastic Surgeon. The relative firmness of Restylane can be an advantage in certain areas where a more robust filler can provide better correction.
Juvederm is a smooth consistency gel while Restylane is a particulate or granular gel.
Also, Juvederm is 35% more cross-linked hyaluronic acid /ml compared to Restylane.
Juvederm appears to work better in the lips than Restylane.
Juvederm is described as "next generation" because the gel is smoother than Restylane and works on all skin types and colors.
Advantages of Juvederm over Restylane:
- Juvederm is softer, more malleable and easier to inject (i.e. better flow characteristics). There may possibly be less pain and bruising with Juvederm due to these better flow characteristics.
- Juvederm may last longer than Restylane because the degree of cross-linking with Juvederm which is associated with persistence of effect.
Juvederm injectable gel is the only smooth consistency gel—other hyaluronic acid dermal fillers currently on the market are made of granular consistency gels.*
JUVEDERM
RESTYLANE
*Dry test, extrusion of a small amount (≈.025 mL) of Juvederm injectable gel and Restylane onto a glass surface at 9x magnification.
†Restylane is a registered trademark of Q-Med AB.
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Some Juvederm side effects include:
- temporary discomfort
- localized bleeding or bruising at the injection site
- discoloration
- mild to moderate redness
- swelling
- edema
- stinging or pain on pressure at injection site
- swellings or nodules may develop at the injection site
- abcess
- granuloma
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The beneficial effects of Juvederm usually last six to nine months. How long the effects last varies from person to person depending on skin type, the area treated, and the volume injected. Juvederm is gradually broken down and absorbed by the body, so the lines, wrinkles or lips will ultimately return to their previous appearance without top up treatments. The outcome can be optimized and made to last longer with a follow-up procedure a few weeks after the initial treatment. In some cases, the effect may last for up to one year.
The average life of Juvederm in the lips is 6 months because of the high vascularisation of the lips.
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Before your Juvederm treatment you should remove any makeup so that the doctor can see where your wrinkles are. You should also stop taking any medications which might lead to bruising or bleeding such as aspirin or any blood thinners.
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In the hours following the injection you should avoid excessive facial expressions.
Do not expose yourself to gel, sunlight or excessive heat (UV, sauna, Turkish baths etc.) for long times for two following the Juvederm injections.
Do not touch, handle or massage the site injected.
Make sure that you're not aggressively using makeup within the first hour or two after the Juvederm injections. Make up and usual care may be used on the day after treatment.
Within the first 24 hours, patients should avoid strenuous exercise, extensive sun or heat exposure and alcoholic beverages. Exposure to any of the above may cause temporary redness, swelling, and/or itching at the injection sites.
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Juvederm is non-animal, stabilized hyaluronic acid. Juvederm is created through special biosynthesis techniques. Collagen is derived directly from humans, cows (bovine) or pigs (porcine). Since Juvederm is non-animal based there is no need to perform an allergy test before using Juvederm. With collagen-based fillers allergic reactions are possible in 3 to 4% of people treated. Juverderm lasts two to three times as long as collagen-based fillers last.
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Most people can return to work immediately after Juvederm treatment of fine lines and wrinkles. If you have Juvederm injections in your lips, swelling may last for several days and you may want to take some time off of work.
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Advantages of Juvederm over other dermal fillers:
- Juvederm is softer, more malleable and easier to inject (i.e. better flow characteristics). There may possibly be less pain and bruising with Juvederm due to these better flow characteristics.
- Juvederm may last longer than other dermal fillers because the high degree of cross-linking with Juvederm which is associated with persistence of effect.
- No allergy skin tests are needed prior to receiving Juvederm treatments.
- Juvederm is the only smooth consistency hyaluronic acid gel. Other hyaluronic acid dermal fillers are particulate or granular gel.
- Your treatment can be tailored to your needs because Juvederm comes in two formulas, Juvederm Ultra for contouring and adding volume to smooth wrinkles and folds, and Juvederm Ultra Plus, a more robust formulation used to correct deeper wrinkles and folds.
- Long-lasting results, up to 1 year.
- Zero, or minimal, down-time following treatment.
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According to Allergan, the claims surrounding Juvederm are that there is increased cross-linking. This creates a firmer structure, a firmer substrate, and therefore Juvederm will last longer than the rest of the hyaluronic acid dermal fillers. In reality, this probably means a one or two month increase in the length of time the effects last. Juvederm is also very smooth compared to many of the other dermal fillers.
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Juvederm injectable gel is a "next generation" hyaluronic acid dermal filler that provides volume and is used to treat wrinkles and folds resulting from a loss of volume beneath the surface of the skin such as perioral lines and nasolabial folds (lines around your mouth and nose). Juvederm restores your skin's volume for a smooth, natural look and feel. BOTOX Cosmetic is not a filler. BOTOX Cosmetic relaxes muscle activity and is used to treat moderate to severe lines caused by the dominant frown muscles between the eyebrows (the glabellar area). This allows the two vertical lines between the brows, often referred to as the "11," to temporarily diminish for a smoother appearance.
Juvederm and Botox are different types of wrinkle treatments. Botox is a muscle "relaxer". Juvederm (like Restylane) is a dermal filler. As a general rule, Botox is used for wrinkles on the upper half of the face and Juvederm is used for wrinkles on the lower half of the face (especially around the mouth). The reason for this is that expression muscles cause the wrinkles on the upper half of the face (for example, a frown line when you frown or "crow’s feet" when you squint). Botox relaxes these muscles and the wrinkles fade.
Wrinkles form on the lower half of the face due to loss of volume. Cosmetic dermal fillers like Juvederm replace this lost volume and fill in the line or wrinkle. So to summarize: Juvederm is a hyaluronic acid filler that is for the treatment of wrinkles on the lower face. Botox is a relaxer that is used for totally different wrinkles on the upper half of the face.
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The types of Juvederm available include:
- Juvederm 18 - When injected into the superficial dermis, the fluid version Juvederm 18 helps to fill fine wrinkles such as crow's feet or peri-oral wrinkles.
- Juvederm 24 - When injected into the middle dermis, the dense version, Juvederm 24 fills forehead wrinkles, glabellar lines, mild naso-genian folds and cheek wrinkles.
- Juvederm 30 - When injected into the middle/deep dermis the densest version, Juvederm 30, fills deep naso-genian folds, returns volume to your lips, sculpts your cheeks and restores the oval shape to your face.
- Juvederm 24HV (also called Ultra) - Juvederm 24 HV has a slightly higher viscosity than Juvederm 24, and can be injected into deeper wrinkles and folds. This will also last slightly longer than Juvederm 24.
- Juvederm 30HV (also called Ultra Plus)
- Juvederm Ultra (also called 24HV) - The "Ultra" product provides versatility in contouring and volumizing of facial wrinkles and folds.
- Juvederm Ultra Plus (also called 30HV) - The "Ultra Plus" product is a more robust formulation for volumizing and correcting deeper folds and wrinkles.
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Yes, Juvederm injections are FDA-approved. Juvederm was granted FDA approval at the beginning of 2007.
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Our Juvederm cost is ______. Your physician’s office will most likely charge you considerably more than that. Speak to you physician about purchasing Juvederm from Medical Device Source so that you can save on your Juvederm cost.
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Juvederm Ultra injectable gel is supplied in individual treatment syringes with 30-gauge needles for single patient use and ready for injection (implantation). The volume in each syringe is as stated on the syringe label and on the carton. The contents of the syringe are sterile and non-pyrogenic.
Juvederm Ultra Plus injectable gel is supplied in individual treatment syringes with 27-gauge needles for single patient use and ready for injection (implantation). The volume in each syringe is as stated on the syringe label and on the carton. The contents of the syringe are sterile and non-pyrogenic.
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Juvederm is manufactured by:
Corneal
31, rue des Colonnes du Trône
75012 Paris
France
Juvederm owned by Corneal Industrie S.A.S.
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